Clinical Applications

The majority of my research collaborations to date are with researchers on the Pulmonary and Critical Care Medicine team at Weill Cornell Medicine (WCM). Other long-term research experiences includes applications within neurology (cognitive decline/brain volumes), neuroepigenetics (effects of sugar consumption), canine genomics, and associations with air pollution and kidney disease.

This is a selected list of clinical application manuscripts I’ve co-authored. A full list of published manuscripts and papers-under-review is available on my CV.

*Indicates authors contributed equally to the work.

Selected Clinical Application Publications

Hoffman KL, Milazzo F, Williams NT, et al. Independent and joint contributions of physical disability and chronic pain to incident opioid use disorder and opioid overdose among medicaid patients. Psychological Medicine. Published online 2023:1-12. doi:10.1017/S003329172300332X

*Schenck EJ, *Hoffman KL, Oromendia C, et al. A Comparative Analysis of the Respiratory Subscore of the Sequential Organ Failure Assessment Scoring System. Annals of the American Thoracic Society. 2021;18(11):1849-1860. doi:10.1513/AnnalsATS.202004-399OC

*Gómez-Escobar LG, *Hoffman KL, Choi JJ, et al. Cytokine signatures of end organ injury in COVID-19. Scientific Reports. 2021;11(1):12606. doi:10.1038/s41598-021-91859-z

Schenck EJ, Hoffman K, Goyal P, et al. Respiratory Mechanics and Gas Exchange in COVID-19–associated Respiratory Failure. Annals of the American Thoracic Society. 2020;17(9):1158-1161. doi:10.1513/AnnalsATS.202005-427RL

Torres LK, Hoffman KL, Oromendia C, et al. Attributable mortality of acute respiratory distress syndrome: A systematic review, meta-analysis and survival analysis using targeted minimum loss-based estimation. Thorax. 2021;76(12):1176-1185. doi:10.1136/thoraxjnl-2020-215950

Price DR, Hoffman KL, Oromendia C, et al. Effect of Neutropenic Critical Illness on Development and Prognosis of Acute Respiratory Distress Syndrome. American Journal of Respiratory and Critical Care Medicine. 2021;203(4):504-508. doi:10.1164/rccm.202003-0753LE

Price DR, Hoffman KL, Sanchez E, Choi AMK, Siempos II. Temporal trends of outcomes of neutropenic patients with ARDS enrolled in therapeutic clinical trials. Intensive Care Medicine. 2021;47(1):122-123. doi:10.1007/s00134-020-06263-4

Zhang WZ, Hoffman KL, Schiffer KT, et al. Association of plasma mitochondrial DNA with COPD severity and progression in the SPIROMICS cohort. Respiratory Research. 2021;22(1):126. doi:10.1186/s12931-021-01707-x

Schenck EJ, Hoffman KL, Cusick M, Kabariti J, Sholle ET, Campion TR. Critical carE Database for Advanced Research (CEDAR): An automated method to support intensive care units with electronic health record data. Journal of Biomedical Informatics. 2021;118:103789. doi:10.1016/j.jbi.2021.103789

10.

Su C, Hoffman KL, Xu Z, et al. Evaluation of Albumin Kinetics in Critically Ill Patients With Coronavirus Disease 2019 Compared to Those With Sepsis-Induced Acute Respiratory Distress Syndrome. Critical Care Explorations. 2021;3(12):e0589. doi:10.1097/CCE.0000000000000589

11.

Zhang WZ, Rice MC, Hoffman KL, et al. Association of urine mitochondrial DNA with clinical measures of COPD in the SPIROMICS cohort. JCI insight. 2020;5(3):133984. doi:10.1172/jci.insight.133984

12.

Rahman A, Schelbaum E, Hoffman K, et al. Sex-driven modifiers of Alzheimer risk: A multimodality brain imaging study. Neurology. 2020;95(2):e166-e178. doi:10.1212/WNL.0000000000009781

13.

*Price DR, *Benedetti E, Hoffman KL, et al. Angiopoietin 2 Is Associated with Vascular Necroptosis Induction in Coronavirus Disease 2019 Acute Respiratory Distress Syndrome. The American Journal of Pathology. 2022;192(7):1001-1015. doi:10.1016/j.ajpath.2022.04.002